Secteur: MedTech

MedTech

Well Bones

Bone diseasesDiagnosticMedical deviceUltrasound

Ultrasound to visualize blood flow in trabecular or cortical bones in bone and joint diseases

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Ref. No.: MA00635

Summary

Karim Ghoufiri

Business Developer

Technology

  • First ultrasound technology to see inside bones by correcting and exploiting complex ultrasound wave physics in bones.
  • The technology provides 3 biomarkers:
    • Anatomy (thickness of bone cortex)
    • Tissue quality (porosity and microstructure)
    • Blood flow (flowing blood volume, blood flow velocity and direction)

 

 

Market

  • Applications:
    • Osteoarthritis (diagnosis, and development of a biomarker for clinical trials on therapies)
    • Osteoporosis / osteonecrosis
    • Osteochondritis dissecans
    • Spondyloarthritis / rheumatoid arthritis / psoriatic arthritis
    • Bone tumors
    • Fracture healing

 

Development status

  • PoC with an ultrasound probe and visualization software
  • Ongoing clinical study

 

IP

  • Patent family filed in 2022
    • PCT/FR2022/050283
    • Pending in EP/US/CA

 

Valorisation strategy

  • Startup
MedTech

Berto Vision

CharacterizationMicroscopyQPI

Signal amplification in self-referenced quantitative phase microscopy

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Ref. No.: MA00655

Summary

Othman Guenoun

Business Developer

Technology

  • The invention aims to increase the signal-to-noise ratio of self-referencing quantitative phase microscopes, thus enabling the detection and characterization of moving nanoobjects with a simple and cheap optical set-up.
  • The module fits onto standard cameras and requires a single image capture, as opposed to techniques that average hundreds of images. This enables objects to be tracked in time and space.
  • Sensitivity > 10 MDa (virus, ribosome, antibody…). Measures cell size, mass, density and growth.
  • Label-free (versus fluorescence that can disturb cells), no preparation (faster process).

 

 

Market

  • Biology: live cell imaging, detection of vesicles, viruses, characterization and quality control of LNP
  • Chemistry: characterization of nanoparticles, monitoring of chemical or electrochemical reactions
  • Industry: material quality control and temperature mapping with micrometric spatial accuracy

 

Development status

  • PoC demonstrating detection at 40 nm (polystyrenes in water on model objects)

 

IP

  • Patent filed in 2022
  • EP US CN JP CA

 

Valorisation strategy

  • Licensing
MedTech

ALEF

ElectrocodemedtechNerve repair

An innovative medical device for peripherical nerval damage repair

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Ref. No.: MA00673

Summary

Karim Ghoufiri

Business developper

Technology

  • Implantable and resorbable medical device for electric field-directed AXONAL REGROWTH and guidance in treatments of traumatic peripheral, nerve sections.
  • This technology is complementary to nerve conduits that work only on small nerve sections at the moment (under 2 – 3 cm)
  • The electrodes on the device enhance the axonal regeneration and could promote nerve repair on long gap sections (over 2 – 3 cm)

Results are visible only two weeks after the section.

 

Market

  • ALEF technology enhances existing nerve conduits with active electrical stimulation to guide axonal regeneration. It enables long-gap nerve repair as an alternative to autografts while also improving outcomes in short-gap injuries. With 1.08 million peripheral nerve surgeries annually, the market potential is significant.

 

Development status

  • TRL 3 (In-vivo results)

 

IP

  • PCT Patent application filed 2023/05/24 under n°PCT/IB2023/000262

 

Valorisation strategy

  • Research of industrial partner
  • Possible new developments based on industrial specifications
MedTech

US Droplet – Sonophoresis

Drug DeliverySonophoresisUltrasound

Ultrasound-triggered release of active ingredients contained within a hydrogel or a double-emulsion

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Ref. No.: MA00665

Summary

Karim Ghoufiri

Business Developer

Technology

  • Microfluidic encapsulation process of active ingredients in liposomes for their controlled differential release in time and space using ultrasound: the vesicles can be opened and then reclosed when the pulse stops.
  • These vectors can be administered intravenously or incorporated into a hydrogel for topical application.
  • The carrier may consist of a double emulsion, either hydrophilic and/or hydrophobic.
  • Low-frequency ultrasound is used, featuring an innovative mechanism that destabilizes the electrostatic interactions within the hydrogel network.
  • No cavitation or overheating occurs, which could otherwise damage tissues.

 

Market

  • Two versions: for topical use (patch or dressing) and for intravenous use.
  • Active ingredients: growth factors, antibiotics, drugs, hyaluronic acid, etc.
  • Potential applications: rheumatology, dermatology, oncology, cosmetics, diabetology, physiotherapy.

 

Development status

  • US Droplet : encapsulation of fluorescent probes in double emulsions subjected to ultrasound treatment (7 min, duty cycles 5–50%) shows that molecule release increases proportionally with treatment intensity
  • Sonophoresis: encapsulation of BSA in alginate gels treated with focused ultrasound (5%, 20–60 min) results in protein release correlated with exposure time, despite only ~2% of the volume being directly exposed.

 

IP

  • Patent application filed on December 16, 2022 (WO2024/126605) – CN, KR, US, JP, EP.
  • Patent application filed on June 21, 2021 (WO2022/268284) – US, EP.

 

Valorisation strategy

  • Licensing

 

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