Summary
Alexis Maloux
Business Developer
Technology
- New macroporous biomaterials that mimic native tissues, thanks to an innovative process: topotactic fibrillogenesis of collagen I + ice templating.
- A process that is easy to industrialize by adjusting the parameters to obtain complex shaped materials with properties that can be modulated according to the area to be reconstructed.
- These materials have been shown to regenerate a wide range of soft tissues (muscles, tendons, ligaments, nerves, etc.)
- Current material production speed: 10mm per minute.
Market
- First application in vascular and thoracic surgery, to facilitate grafting of small-diameter arteries, and upper airway repair.
- Second application to enhance 3D cell culture models, for drug screening.
Development status
- Development of the protocol for freezing and topotactic fibrillogenesis in the gas phase and then in the liquid phase.
- Development of double-layer materials
- Demonstration of the functionalization of materials (4mm internal diameter, 2mm thickness – cell colonization within a few days) & successful leak testing)
- In vivo implantation in mice for applications as muscle grafts.
- Development of double-layer materials of a size compatible with tracheal implantation (diameter 21 mm, thickness 4.25 mm) – Implantation in sheep on going
IP
- A patent application filed in 2023
- PCT/IB2023/000465
Valorisation strategy
- Co-development
- Licensing